DOWNLOAD: Villarreal vs Barcelona (1-4) Highlights

Barcelona boss Setien, however, makes just two changes to the side that drew 2-2 with Atletico Madrid in their last outing. Rakitic and Puig are named among the substitutes, while Griezmann and Roberto are brought in to play from the start.

Barcelona substitutes: Jorge Cuenca, Alex Collado, Neto, Dani Morer, Martin Braithwaite, Ivan Rakitic, Ansu Fati, Ronald Araujo, Inaki Pena, Riqui Puig, Arthur, Monchu.

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Barcelona XI (4-3-3): Marc-Andre ter Stegen; Nelson Semedo, Gerard Pique, Clement Lenglet, Jordi Alba; Sergi Roberto, Sergio Busquets, Arturo Vidal; Lionel Messi, Luis Suarez, Antoine Griezmann.

Villarreal substitutes: Fernando Nino, Andres Fernandez, Bruno Soriano, Carlos Bacca, Manuel Morlanes, Javier Ontiveros, Moi Gomez, Sergio Lozano, Xavi Quintilla, Sofian Chakla, Ruben Pena, Manu Trigueros.

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Villarreal XI (4-4-2): Sergio Asenjo; Mario Gaspar, Raul Albiol, Pau Torres, Alberto Moreno; Samuel Chukwueze, Andre Zambo Anguissa, Vicente Iborra, Santi Cazorla; Gerard Moreno, Paco Alcacer.

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