Real Madrid are dealing with a lot of injuries at the moment, including to Gareth Bale and Toni Kroos. Solari still makes three changes to the side that beat Leganes in the cup, however, with Varane, Modric and Carvajal starting in place of Lucas Vazquez, Odriozola and Ceballos. Vazquez is suspended for this one, but that is still not enough for Isco to get a rare start. Thibaut Courtois is out for a couple of weeks with injury, which allows Navas to retain his place in goal. January signing Diaz made his debut against Leganes and is on the bench again for this one.
REAL MADRID (3-5-2): Keylor Navas; Raphael Varane, Sergio Ramos, Nacho; Daniel Carvajal, Luka Modric, Casemiro, Federico Valverde, Sergio Reguilon; Vinicius Junior, Karim Benzema.
SUBS: Sergio Leon, Loren Moron, Zouhair Feddal, Joel Robles, Ryad Boudebouz, Javi Garcia, Cristian Tello.
REAL BETIS (4-3-3): Pau Lopez; Antonio Barragan, Aissa Mandi, Marc Bartra, Francis; Giovani Lo Celso, William Carvalho, Andres Guardado; Joaquin, Antonio Sanabria, Sergio Canales.