United have made nine changes to their side from the team that beat Newcastle during the week. Only Jones and Mata retain their places in the line-up. Romero replaces De Gea in between the sticks, while Dalot, Darmian and Young come into the back four. McTominay, Fred and Pereira get the nod to start in the middle of the park. Lukaku and Sanchez play in a three-man attacking line with Mata.
SUBS: Chris Gunter, John O’Shea, Sone Aluko, Modou Barrow, Yakou Meite, Sam Walker, Ryan East.
READING (4-2-3-1): Anssi Jaakkola; Andy Yiadom, Tiago Ilori, Liam Moore, Omar Richards; Liam Kelly, Andy Rinomhota; Garath McCleary, John Swift, Callum Harriott; Danny Loader.
SUBS: Victor Lindelof, Marcus Rashford, Anthony Martial, Lee Grant, Marouane Fellaini, James Garner, Tahith Chong.
MANCHESTER UNITED (4-3-3): Sergio Romero; Diogo Dalot, Matteo Darmian, Phil Jones, Ashley Young; Fred, Scott McTominay, Andreas Pereira; Juan Mata, Romelu Lukaku, Alexis Sanchez.